I was talking to a co-worker about this over lunch and he said the worst one he's run into was Excel on the Mac. He thought it was ridiculous that Microsoft would think Ctrl-U was even close to hitting the F2 key that Windows users use.1 I sat there for a second and said I always use F2 key when I edit cells in Excel. We argued for about 10 minutes and finally made a bet on whether I was right or not.
We sat down at my desk and started Excel, opened a file and went to edit a cell. Just as I was about to hit F2 I remembered I had set up a Keyboard Maestro macro to remap F2 2 key to Ctrl-U. I hit F2 and sure enough, I was in edit mode for the cell.
My buddy's jaw dropped and immediately asked how I had remapped the keyboard for just Excel to do that. I had to sheepishly admit that it wasn't that complicated.
He argued that I didn't win the bet because I forgot to mention I was using another program to remap the key. We called it draw because he was just happy to not have to use the horrendous Ctrl-U key combo. One of the few things I think are messed up on a Mac is how companies think they need to re-invent the wheel with keyboard shortcuts.